In this presentation, results of a collaborative project between Dr. Kristina W. Whitworth at Baylor College of Medicine in Houston, Texas with INMA investigators will be described.  Briefly, the study goals are to evaluate the impacts of pre- and post-natal fine particulate matter (PM2.5) exposure on children’s cognitive and motor function. Daily residential PM2.5 exposures were estimated using random forest models from which weekly average PM2.5 exposure during the prenatal period and 4-week averages during the postnatal period were estimated.  Distributed lag non-linear models were then applied to explore periods of susceptibility to PM2.5 in each period with neurodevelopmental outcomes among preschool-aged children (i.e., cognitive and motor function based the McCarthy Scales of Children’s Abilities (MSCA)) and school-aged children (i.e., attentional function, psychomotor speed, and working memory based the attentional network test, finger-tapping test and n-back test, respectively).