Amaia Elicegui Aguirre– Doktoratu aurreko ikaslea Biodonostia OIIan.

Biodonostia OIIko-Ekitaldi Aretoan.



Amyotrophic Lateral Sclerosis (ALS) is the most frequent Motor Neuron (MN) disease that leads to the degeneration of both upper and lower MNs, muscle atrophy and consequent progressive loss of voluntary movements. Whereas the etiopathogenesis of ALS is still uncertain, growing evidence guide toward non-cell autonomous mechanisms that trigger neuromuscular junction (NMJ) dismantlement and MN degeneration. Moreover, NMJ dismantlement is associated to an insufficient capacity of Terminal Schwann Cells (TSCs) to restore synaptic reinnervation and ensuing nerve retraction. Finally, alterations in the postsynaptic endplate and early metabolic changes in muscle have also been observed in the early stages of the disease. In this seminar, I will present early preliminary results of my PhD project based on the study of the role of the NMJ in ALS, highlighting its contribution to the neurodegeneration through backward-signaling processes, considering the crosstalk muscle (stem cells)-NMJ, as a newly uncovered mechanism for a peripheral etiopathogenesis of the disease.