Neurodegenerative diseases are chronic and multifactorial disesaes in which age, genetic, environmental factors, life style and diet represent the principal risk factors for neurodegeneration. Currently, the principal biomodels used to study the mechanisms and progression of neurodegeneration are animal models. However, more than 90% of the treatment in animal models do not reach the clinical experimentation. This emergency is exacerbated by extra-scientific decisions directed to the limitation of animal models for drug development. Human iPSC-derived biomodels represent a valid tool to study the brain neurodegeneration and complement drug development. Human brain organoids are 3D miniaturized cultures of a human brain that can be generated from iPSCs derived from a healthy donor or a patient. At The Basque Biomodels Platform for Human Research (BBioH) we generate human brain organoids, especially from midbrain and forebrain, to study neurodegeneration development and to propose a comprehensive model to study the mechanisms of neurodegenerative diseases.