Saioa García-Serrano – Investigadora predoctoral en IIS Biodonostia.

Aula de Formación-IIS Biodonostia.



Multiple sclerosis is an autoimmune and demyelinating disease of the central nervous system. Genome-wide association studies performed in the last decades have been successful identifying genetic variants that confer a greater risk for developing MS. On the other hand, transcriptomic studies also have revealed different expression patterns according to disease, highlighting the importance of the non-coding genome. In this context, functional studies trying to understand how genetic variation can contribute to the disease, have identified that some of the variants may exert their function by affecting the expression of genes, which are defined as expression quantitative trait locis.