Molecular Oncology

Group leader: Charles Lawrie, Ph.D.

Biodonostia HRI. Ikerbasque Research Professor.
Dr. Charles Lawrie obtained his BA Hons in Biochemistry, MA and DPhil at Trinity College, University of Oxford. Having held several postdoctoral positions at the University of Oxford, he launched and was Principal Researcher of the Lymphoid Malignancy Research Group (LMRG) at the Nuffield Department of Clinical Laboratory Sciences (NDCLS), part of the University of Oxford’s Medical Sciences Division. He joined the Biodonostia HRI in 2011 as an Ikerbasque Research Professor, as well as Coordinator of the Oncology Area and Leader of the Molecular Oncology Research Group.
Since then, he has obtained more than €3.5 million in competitive funding at regional, national and European level. Dr. Lawrie has published more than 100 publications, including two books and 9 book chapters. This production has been cited more than 6,500 times, obtaining an h-index of 36 in 2020. He is the co-inventor of 4 patents and has directed 13 doctoral theses. He was elected Fellow of the Royal College of Pathologists (FRCPath) and is a University Research Lecturer at the University of Oxford.

Strategic Objectives

  • To understand the molecular pathogenesis of haematological diseases (and other types of cancer) and the translation of that knowledge to clinical environments.
  • To identify and develop new biomarkers for cancer diagnosis and prognosis.

Main lines of research

  • The identification and assessment of the utility of circulating microRNA/RNA as non-invasive cancer biomarkers.
  • Identification of factors behind drug resistance and new therapeutic procedures to treat cancer by using coding viral libraries for siRNA/microRNA.
  • Identification of new mutations on the site of target gene-microRNA interaction and in the sequence of the same microRNA associated with cancer.
  • Characterisation of the target miRNA:mRNA interface in cancer.

Team Members

Name Surname Center E-mail
María Araiz Ramírez Donostialdea IHO
Maria Arestín Muruzabal Biodonostia HRI
María Armesto Álvarez Biodonostia HRI
Laura Basterretxea Badiola Donostialdea IHO
Enrique Bengoechea Nerecan Donostialdea IHO  –
Iraide Bernal Simón Donostialdea IHO  –
Francisco José Carretero Domínguez Biodonostia HRI
Izaskun Ceberio Echechipia Donostialdea IHO
Ana Gálvez Vergara Biodonostia HRI
June Gurrutxaga Navas Biodonostia HRI
Bruno Iraola Sáenz Biodonostia HRI
Maitane Márquez López Biodonostia HRI
Stéphane Nemours Biodonostia HRI
Carlos Manuel Panizo Santos Donostialdea IHO
Carla Solé Cañadas Biodonostia HRI
Beatriz Suárez Álvarez Biodonostia HRI


Scientific Output