Breast cancer

Group co-leader: Isabel Álvarez, M.D.

Donostialdea IHO E-mail isabelmanuela.alvarezlopez@osakidetza.eus

Group co-leader: María Muñoz Caffarel, PhD.

Biodonostia HRI E-mail maria.caffarel@biodonostia.org
Dr. Isabel Manuela Álvarez López has a Degree in Medicine and Surgery obtained at the University of Navarra in 1985 and has been a Specialist in Medical Oncology since 1989. An Attending Physician since 1990 with the Medical Oncology Unit of Donostia University Hospital (Donostialdea IHO) (she currently works in the Gipuzkoa Cancer Management Unit run by Osakidetza-SVS jointly with Onkologikoa). She has fundamentally developed her activity in the Breast Cancer Area. Founding member of the Cooperative Research Group in Breast Cancer (GEICAM) and member of its Board of Directors. Leader of the Breast Cancer Group at the Biodonostia HRI since 2021 and, since 2020, shares joint leadership of the Group with Dr. María Muñoz Caffarel. She has participated in more than 30 clinical trials on multicentric breast cancer, both in collaboration with the pharmaceutical industry and in academic studies. She has more than 30 publications related to breast cancer. In the Research Group, as well as clinical trials, work is underway on the areas of tumour heterogeneity, hormone sensitivity and inflammation in breast cancer (studies funded in public calls) Dr. María Muñoz Caffarel is an Ikerbasque Research Associate and Miguel Servet Researcher at the Biodonostia HRI, where she is Co-Leader of the Breast Cancer Research Group within the Oncology Area. She has a Degree in Biochemistry (National Award) from the UCM (Madrid), where she completed her PhD in 2008. She has more than 5 years’ international experience at the University of Cambridge (UK), as well as having spent study periods at the Curie Institute (France), CNIO and IDIBELL (Spain). Since she joined the Biodonostia HRI in 2015, she has obtained more than €1 million as a Principal Researcher in public and private calls at regional, state and international level. She is the author of 28 scientific articles, 3 book chapters and the co-inventor of one patent; her publications have been highly cited (h-index of 17 > 1400 citations). She has directed two doctoral theses and is currently directing another 3. She is a Guest Professor on three master’s degrees (UPV/EHU and UFV) and member of the Board of Directors of ASEICA (Spanish Association for Cancer Research), where she coordinates the ASEICA-Youth work group. She is also President of the Biodonostia HRI Equality Committee and participates in other activities related to women and science. She similarly participates in dissemination activities, giving talks to associations of cancer patients and to the general public (Pint of Science, Donostia WEEK-INN).

Strategic Objectives

  • To contribute to the development of programmes which optimise a personalised approach to the treatment of breast cancer patients, taking into account the specific characteristics of both the tumour and the cancer patient.
  • Clinical research: To continue and promote the creation of clinical trials to develop new diagnostic and therapeutic strategies, and more specifically studies into new drugs.
  • Developing new programmes for translational research, either as independent studies or as studies in parallel to or associated with clinical trials. The goal is to develop and implement new molecular techniques that may be diagnostically and predictively relevant to the optimisation of treatments suitable to each molecular subtype.
  • Development of studies in the areas of epidemiology and the follow-up of breast cancer patients.

Main lines of research

  • Study of the presence and prognostic significance of status heterogeneity in the receptors between the primary tumour and the synchronous lymph node metastasis in hormone receptor-positive breast cancers.
  • Circulating tumoural stem cells in breast cancer.
  • Comparison between the clinical-pathological features of interval breast cancers (IC) and those detected in the programmed screening among the participants in the Basque Health Service’s breast cancer detection programme.
  • Use of next-generation sequencing technology to analyse genetic differences between the primary tumour and metastatic sites.
  • Identification and validation of circulating miRNA/RNA as non-invasive markers for breast cancer.
  • Use of shRNA/miRNA coding viral libraries in order to identify factors of resistance to drugs and new therapies in breast cancer.

Team Members

Name Surname Center E-mail
Andrea Abaurrea Larrañaga Biodonostia HRI andrea.abaurrea@biodonostia.org
Luis Alberto Alvarez Cuesta Onkologikoa Fundazioa laalvarez@onkologikoa.org
Nerea Ancizar Lizarraga Donostialdea IHO nerea.ancizarlizarraga@osakidetza.eus
Haritz Arrieta Etxeberria UPV-EHU harrieta@onkologikoa.org
Peio Azcoaga Azcoaga
María Cristina Churruca Galaz Donostialdea IHO cristinamaria.churrucagalaz@osakidetza.eus
María Díez Zubizarreta Biodonostia HRI maria.diez@biodonostia.org
Marta Fernández Calleja Donostialdea IHO mfernand@chdo.osakidetza.eus
Elena Guimón Olaizola Donostialdea IHO elena.guimonolaizola@osakidetza.eus
Ainhara Lahuerta Martínez Onkologikoa Fundazioa
Joanna Ines López Velazco Biodonostia HRI joannaines.lópez@biodonostia.org
Sara Manzano Figueroa Biodonostia HRI sara.manzano@biodonostia.org
Ana Paisán Ruiz Donostialdea IHO ana.paisanruiz@osakidetza.eus
Laura Pulido López Biodonostia HRI laura.pulido@biodonostia.org
Marta Rezola Bajineta Donostialdea IHO
Jose María Urraca De La Serna Donostialdea IHO josemaria.urracadelaserna@osakidetza.eus
Ander Urruticoechea Ribate Onkologikoa Fundazioa anderu@onkologikoa.org

 

Scientific Output

ESTUDIO DE LAS INTERACCIONES ENTRE EL MICRO-AMBIENTE TUMORAL Y LA VIA DE OSMR PARA ENCONTRAR NUEVAS DIANAS TERAPEUTICAS PARA LOS TUMORES DE MAMA TRIPLE NEGATIVO
Código: PI15/00623
Investigador Principal (IP): MARIA MUÑOZ CAFFAREL
Entidad Financiadora: ISCIII INSTITUTO DE SALUD CARLOS III
Fecha de Inicio: 2016-01-01
Fecha de finalización: 2020-11-30
Importe Concedido: 110.715,00 €
BUSQUEDA MEDIANTE EXOMAS DE GENES RELACIONADOS CON CANCER DE MAMA FAMILIAR EN FAMILIAS BRCA NEGATIVAS
Código: BIO15/CA/042/BD
Investigador Principal (IP): MARIA CRISTINA CHURRUCA GALAZ
Entidad Financiadora: EITB MEDIA, SAU
Fecha de Inicio: 2016-06-01
Fecha de finalización: 2020-06-30
Importe Concedido: 39.554,90 €
ATACAR LA VIA DEL RECEPTOR DE ONCOSTATINA M PARA MEJORAR EL TRATAMIENTO DEL CANCER DE MAMA: NUEVAS ESTRATEGIAS TERAPEUTICAS Y DIAGNOSTICAS
Código: 2017111011
Investigador Principal (IP): MARIA MUÑOZ CAFFAREL
Entidad Financiadora: DEPARTAMENTO DE SALUD
Fecha de Inicio: 2017-12-21
Fecha de finalización: 2021-01-17
Importe Concedido: 62.551,64 €
PAPEL DE LA CITOQUINA PRO INFLAMATORIA ONCOSTATINA M EN EL CANCER DE MAMA METASTASICO: NUEVAS ESTRATEGIAS TERAPEUTICAS Y DIAGNOSTICAS
Código: PI18/00458
Investigador Principal (IP): MARIA MUÑOZ CAFFAREL
Entidad Financiadora: ISCIII INSTITUTO DE SALUD CARLOS III
Fecha de Inicio: 2019-01-01
Fecha de finalización: 2021-12-31
Importe Concedido: 105.270,00 €
BONO TECNOLOGICO 2019 - NARU INTELLIGENCE. STEP: SISTEMA DE MEJORA DE LA CALIDAD DE VIDA DE PACIENTES ONCOLOGICOS
Código: 0507/2019/0205
Investigador Principal (IP): NEREA ANCIZAR LIZARRAGA
Entidad Financiadora: FOMENTO DE SAN SEBASTIAN SA
Fecha de Inicio: 2019-10-01
Fecha de finalización: 2020-10-31
Importe Concedido: 12.500,00 €
APOYO A LA ESTRUCTURACION DE UN PLAN DE I+D+I EN EL GRUPO DE TRABAJO RIS-3 MEDICINA PERSONALIZADA
Código: 2020444001
Investigador Principal (IP): ANDER URRUTICOECHEA RIBATE
Entidad Financiadora: DEPARTAMENTO DE SALUD
Fecha de Inicio: 2020-01-01
Fecha de finalización: 2020-12-31
Importe Concedido: 18.755,00 €
IDENTIFICACION DE NUEVOS BIOMARCADORES PARA EL USO DEL TRATAMIENTO HORMONAL PRIMARIO Y DE NUEVAS TERAPIAS PARA TUMORES RESISTENTES EN CANCER DE MAMA LUMINAL
Código: 2020111040
Investigador Principal (IP): MARIA MUÑOZ CAFFAREL
Entidad Financiadora: DEPARTAMENTO DE SALUD
Fecha de Inicio: 2020-12-01
Fecha de finalización: 2023-12-31
Importe Concedido: 61.629,41 €
PROYECTOS PARA INVERSION
Código: 2020-CIEN-000106-01
Investigador Principal (IP): MARIA MUÑOZ CAFFAREL
Entidad Financiadora: DIPUTACION FORAL GIPUZKOA
Fecha de Inicio: 2020-07-09
Fecha de finalización: 2021-09-30
Importe Concedido: 34.000,00 €
IDENTIFICACIÓN DE NUEVOS BIOMARCADORES PARA CARACTERIZAR LA RESPUESTA A TRATAMIENTO HORMONAL PRIMARIO EN CÁNCER DE MAMA LUMINAL.
Código: SEOM20/501
Investigador Principal (IP): ANDER URRUTICOECHEA RIBATE
Entidad Financiadora: SOCIEDAD ESPAÑOLA DE ONCOLOGIA MEDICA
Fecha de Inicio: 2020-10-01
Fecha de finalización: 2021-09-30
Importe Concedido: 23.000,00 €