Multiple Sclerosis

Group co-leader: David Otaegui, Ph.D.

Biodonostia HRI E-mail david.otaegui@biodonostia.org

Group co-leader: Tamara Castillo Triviño

OSI Donostialdea E-mail tamara.castillotrivino@osakidetza.eus
Dr. David Otaegui Bichot graduated in Biochemistry at the University of the Basque Country (UPV/EHU) in 1999 and received his doctorate from the same University in 2007. During his research career he has been a visiting fellow at Columbia University (NYC) and at that of California in San Francisco. Dr. Otaegi is the author of 84 publications (63% of them in Q1) with an h-index of 34. He has 4 pending patent applications and has directed 9 doctoral theses. The Biodonostia HRI Multiple Sclerosis Group, of which he is the Co-Leader, is part of the Spanish Multiple Sclerosis Network and of the Translational Network for the clinical application of extracellular vesicles. Ms. Tamara Castillo Triviño obtained her Degree in Medicine and Surgery at the University of Navarra in 2003. She completed a Master’s Degree Program in Clinical Research at the University of California San Francisco in 2010. Today she is Attending Physician with the Neurological Service of the Donostia University Hospital (Donostialdea IHO), as well as Co-Leader of the Multiple Sclerosis Group at the Biodonostia HRI. She is the author of more than 30 publications and has participated in more than 16 Clinical Studies.

Our Group has been researching Multiple Sclerosis and other neuroimmunological diseases for more than 20 years. We are a multidisciplinary group who combine laboratory research with our everyday work at the clinic, focussing our interests on achieving better understanding of how the pathology functions and the variables which can affect its development. Our research is therefore fundamentally translational and patient-oriented. We also have as our objective to disseminate science and scientific culture by means of disclosing our findings, bringing our projects and outcomes to patients and society.

Strategic Objectives

  • To monitor the clinical variables of Multiple Sclerosis through a database enabling us to better handle the disease.
  • To understand the process of flare-ups and remyelination. Characterisation of the transcriptome and its regulation by means of non-coding RNAs in the different stages of the disease.
  • To understand communication between cells through the extracellular vesicles and their potential use as a biomarker and/or therapeutic tool.
  • To analyse the remyelination processes and the potential approximations for improving these processes by vehiculating snRNA to the Central Nervous System.
  • To study the implication of intestinal microbiota in development of the disease and its potential modulation as a therapeutic tool.
  • To understand the disease as a whole, combining the aspects learned in the different lines in order to generate biomarkers enabling the improved therapeutic handling of each patient.
  • To carry out studies on quality of life, pain, side effects and environmental effects (sun, smoking, etc.) on our patients.
  • To participate in clinical trials.
  • Characterisation of the age effect on the disease, studying paediatric Multiple Sclerosis and the effect of imunosenescence on patients.

Main lines of research

  • Our group has several open lines of research, complementary to one another:
  • Regulation of the Transcriptome.
  • Extracellular vesicles in Multiple Sclerosis.
  • Characterisation of remyelination.
  • Microbiota in autoimmune diseases.
  • Paediatric Multiple Sclerosis.
  • Inmunosenescence.
  • Environmental effects on the progress of the disease.

Team Members

Name Surname
Center E-mail
Ainhoa Alberro Garitano Biodonostia HRI ainhoa.alberro@biodonostia.org
Maialen Arruti Gonzalez Donostialdea IHO maialen.arrutigonzalez@osakidetza.eus
Hirune Crespillo Velasco Biodonostia HRI hirune.crespillo@biodonostia.org
Miriam Gorostidi Aicua Biodonostia HRI miriam.gorostidi@biodonostia.org
Leire Iparraguirre Gil Biodonostia HRI leire.iparraguirre@biodonostia.org
Andrea Iribarren López Biodonostia HRI andrea.iribarren@biodonostia.org
Idoia Mendiburu Arrieta Donostialdea IHO
Laura Moles Alegre Biodonostia HRI laura.moles@biodonostia.org
Maider Muñoz Culla UPV-EHU maider.munoz@biodonostia.org
Alvaro Prada Iñurrategui Donostialdea IHO alvarojose.pradainurrategui@osakidetza.eus
Leire Romarate García Biodonostia HRI leire.romarate@biodonostia.org
Lucia Elena Sepúlveda Sánchez Biodonostia HRI lucia.sepulveda@biodonostia.org
Jose Alberto Suárez Vázquez Biodonostia HRI jose.suarez@biodonostia.org

 

Scientific Output

RETIC RED ESPAÑOLA DE ESCLEROSIS MULTIPLE
Código: RD16/0015/0007
Investigador Principal (IP): DAVID OTAEGUI BICHOT
Entidad Financiadora: ISCIII INSTITUTO DE SALUD CARLOS III
Fecha de Inicio: 2017-01-01
Fecha de finalización: 2021-12-31
Importe Concedido: 112.750,00 €
RNA CIRCULARES Y SU IMPLICACION EN LA ESCLEROSIS MULTIPLE
Código: PI17/00189
Investigador Principal (IP): DAVID OTAEGUI BICHOT
Entidad Financiadora: ISCIII INSTITUTO DE SALUD CARLOS III
Fecha de Inicio: 2018-01-01
Fecha de finalización: 2021-06-30
Importe Concedido: 123.420,00 €
ESTUDIO DE LA INFLUENCIA DE LOS TRATAMIENTOS INMUNOMODULADORES PARA LA ESCLEROSIS MÚLTIPLE EN LA MICROBIOTA
Código: 2018111038
Investigador Principal (IP): TAMARA CASTILLO TRIVIÑO
Entidad Financiadora: DEPARTAMENTO DE SALUD
Fecha de Inicio: 2018-12-14
Fecha de finalización: 2021-12-13
Importe Concedido: 96.316,00 €
PLAKA CONSUMIBLES AVANZADOS PARA CULTIVOS CELULARES
Código: KK-2019/00093
Investigador Principal (IP): DAVID OTAEGUI BICHOT
Entidad Financiadora: DEPARTAMENTO DE DESARROLLO ECONÓMICO E INFRAESTRUCTURAS
Fecha de Inicio: 2019-03-01
Fecha de finalización: 2021-06-30
Importe Concedido: 173.174,82 €
RED TRASLACIONAL PARA LA APLICACION CLINICA DE VESICULAS EXTRACELULARES
Código: RED2018-102411-T
Investigador Principal (IP): DAVID OTAEGUI BICHOT
Entidad Financiadora: MINISTERIO DE CIENCIA E INNOVACION
Fecha de Inicio: 2020-01-01
Fecha de finalización: 2021-12-31
Importe Concedido: 0,00 €
INMUNOSENESCENCIA EN LA ESCLEROSIS MULTIPLE
Código: 2019111039
Investigador Principal (IP): DAVID OTAEGUI BICHOT
Entidad Financiadora: DEPARTAMENTO DE SALUD
Fecha de Inicio: 2019-11-30
Fecha de finalización: 2022-12-31
Importe Concedido: 82.331,00 €
CARACTERIZACION DE LA MICROBIOTA EN LA ESCLEROSIS MULTIPLE: INFLUENCIA EN EL DESARROLLO Y EVOLUCION DE LA ENFERMEDAD
Código: 2019111013
Investigador Principal (IP): LAURA MOLES ALEGRE
Entidad Financiadora: DEPARTAMENTO DE SALUD
Fecha de Inicio: 2019-11-30
Fecha de finalización: 2022-12-31
Importe Concedido: 73.310,00 €
nG20 INVESTIGACION ESTRATEGICA EN TECNOLOGIAS EMERGENTES PARA EL DESARROLLO DE SUPERFICIES AVANZADAS
Código: KK-2020/00001
Investigador Principal (IP): DAVID OTAEGUI BICHOT
Entidad Financiadora: DEPARTAMENTO DE DESARROLLO ECONÓMICO E INFRAESTRUCTURAS
Fecha de Inicio: 2020-03-01
Fecha de finalización: 2021-03-31
Importe Concedido: 102.257,40 €
CLINIMOD-NUEVA HERRAMIENTA PARA LA MONITORIZACION DE MODELOS ANIMALES APLICACION DE ESCLEROSIS MULTIPLE
Código: ZL-2020/00170
Investigador Principal (IP): DAVID OTAEGUI BICHOT
Entidad Financiadora: DEPARTAMENTO DE DESARROLLO ECONÓMICO E INFRAESTRUCTURAS
Fecha de Inicio: 2020-03-01
Fecha de finalización: 2020-12-31
Importe Concedido: 3.534,79 €
INMUNOSENESCENCIA COMO FACTOR DE RIESGO PARA LA INFECCION POR SARS-COV2
Código: COV20/00314
Investigador Principal (IP): DAVID OTAEGUI BICHOT
Entidad Financiadora: ISCIII INSTITUTO DE SALUD CARLOS III
Fecha de Inicio: 2020-04-30
Fecha de finalización: 2021-04-30
Importe Concedido: 44.000,00 €
ESTUDIO DE LA IMPLICACIÓN DE LA EXPRESION ALTERADA DE LOS MICRORNAS EN LOS PACIENTES CON ESCLEROSIS MULTIPLE EN SU FUNCION INMUNITARIA
Código: DFG2020/103
Investigador Principal (IP): MAIDER MUÑOZ CULLA
Entidad Financiadora: DIPUTACION FORAL GIPUZKOA
Fecha de Inicio: 2020-06-23
Fecha de finalización: 2021-09-30
Importe Concedido: 0,00 €