17/05/19

Hizlaria / Ponente: Professor Clare Isacke – Team Leader – Breast Cancer Now Research Centre, Institute of Cancer Research, London, UK.
Data / Fecha: 2019ko maiatzak 17 / 17 de mayo de 2019.
Ordua / Hora:  12:00-13:00.
Lekua / LugarBiodonostia OIIko Prestakuntza Aretoan 3.Solairua. / IIS Biodonostia, Sala de Formación, Planta 3.

Laburpena / Resumen:

The Molecular Cell Biology Team seeks to identify strategies to effectively target key tumour-environment crosstalk pathways to limit metastatic relapse and enhance the efficacy of tumour targeting agents. Cancer-associated fibroblasts (CAFs) and activated pericytes participate in tumour development not only by their impact on cancer cells via paracrine signalling and the deposition of a neoplastic extracellular matrix, but also by their influence on other stromal populations – particularly in promoting a immunosuppressive, pro-tumour microenvironment. Our current research in this area focuses on (a) assessing the efficacy of targeting CAF subpopulations to reduce breast cancer metastatic colonisation, (b) the mechanisms by which CAF-immune cell crosstalk influences tumour growth and response to therapy, and (c) the role of therapy-induced stromal damage in promoting metastatic relapse.

Informazio gehiago / Más Información:
https://www.icr.ac.uk/our-research/researchers-and-teams/professor-clare-isacke
https://www.icr.ac.uk/our-research/research-divisions/division-of-breast-cancer-research/molecular-cell-biology