The research projects carried out at the BioDonostia HRI are as follows:
Animal models in oncology
- Role of FXR and TGR5 in the etiopathogenesis of cholangiocarcinoma: new therapeutic strategy.
- Role of the Epigenetic Alterations Associated with Enzymes in the Physiopathology of Cholangiocarcinoma: New Therapeutic Strategy.
- The effect of Resveratrol and Pravastatin in the prevention and treatment of hepatocarcinoma in a mouse model.
- Oncogenic activity of the transcription factor. Miguel Servet programme, Carlos III Health Institute.
- Characterisation of the tumour stem cell population in Glioblastoma Multiforme.
- Role of – in adult neural stem cells and glioma stem cells.
- Sox transcription factors as therapeutic targets in central nervous system tumours.
- Regulating mechanisms for stem cell ageing.
Animal models of muscular dystrophy:
- Development of advanced cell models of neuromuscular illnesses for therapeutic applications.
- Characterisation of the therapeutic potential of different modulating compounds of the ryanodine receptor in animal and cell models of muscular dystrophy.
Animal models of multiple sclerosis:
- The potential of neurogenic cells derived from skin as remyelination factors in the animal model of multiple sclerosis.
Animal models of Parkinson’s disease:
- Physiopathological mechanisms of the impulse control disorder: study in patients and development of an animal model.
- Effect of stress in the neurodegeneration in Parkinson’s disease.
- Physiopathological mechanisms of the impulse control disorder in Parkinson’s disease. Study in patients and development of an animal model.
- Mechanisms involved in impulsivity in a model of Parkinson’s.
Animal models of Retinitis pigmentosa:
- Retinitis pigmentosa: molecular characterisation and therapeutic approach based on the modulation of the levels of microRNA in mouse models.
Animal models in Tissue engineering:
- Characterisation of treatment with mesenchymal stem cells in distraction osteogenesis.
- Therapeutic utility of Skin-derived Precursor Cells in chronic tendon tears of the rotator cuff in an animal model.
- Injectable bone for treating fractures combining the most advanced hydrogels and allogenic bioactive products.
- Isolation and characterisation of skin stem cells.
Innovative new animal models:
- Development, validation and clinical applicability of a new serum test to detect TNF-alpha.
- Continuous monitoring of pH and/or lactate through an implantable micro-sensor in an animal vault.
- Design and manufacture of a gastric probe that is compatible for monitoring pH.
- Obtaining and characterising biodegradable polymers with antibiotic activity for use in the urinary tract.
- Development of anodised titanium surfaces that are functionalised for biomedical applications. Study of osteointegration in experimentation animals.
Animal models of metabolism and nutrition:
- Effects of statins in body and liver fat.
- Effect of Resveratrol on liver injuries and bacterial translocation produced by total parenteral nutrition in a mouse model.
- Standardisation of the quantification of Iron in Liver by Magnetic Resonance using simulation models (Phantoms).
- Small intestine and apoptosis. The effect of prebiotics, enteral nutrition and parenteral nutrition on intestinal failure.
Spontaneous genetic animal models:
- Ursodeoxycholic acid: new strategy for the treatment of Polycystic Liver Diseases (PLD).