Vaccine Preventable Diseases

Group leader: Gustavo Cilla, M.D., Ph.D.

Donostialdea IHO

Strategic Objectives

  • To study the incidence, prevalence and impact of vaccine-preventable infections and the relationship with epidemiological variables: seasonality, distribution according to sex, age groups, clinical expression, need for hospitalisation or lethality.
  • Phenotypic and genotypic characterisation of the detected strains of bacteria and virus causing vaccine-preventable diseases.
  • Infection caused by Rotavirus and Norovirus: impact in the child population of the Basque Country. Circulating genotypes, genetic drift, analysis of recombinations, relationship with vaccine strains. Assessment of new rotavirus vaccines.
  • Neisseria meningitidis: phenotypes and genotypes of the invasive meningococcal strains and of the isolated strains in asymptomatic carriers. Identification of new circulating clones, including emerging virulent clones.
  • Evaluation of the utility of vaccines, both current and under development.
  • Study of the prevalence and impact of emerging and re-emerging infectious diseases.

Main lines of research

  • Rotavirus: impact in the child population of the Basque Country. Assessment of new anti-rotavirus vaccines.
    • Study of the incidence of infection (by sex or age), seasonality, distribution by age groups, clinical expression and relationship with the type of rotavirus, etc.
    • Evaluation of the impact in the child population by way of the incidence of hospitalisation, the need for paediatric Intensive Care Units support and mortality.
    • Molecular characterisation of the strains of rotavirus that are circulating among the population, the succession of genotypes in rotavirus epidemics, genetic drift, analysis of recombinations, relationship with vaccine strains, etc.
  • Invasive meningococcal disease. Impact of vaccination with conjugate vaccine. Utility of new vaccines
    • Study of the strains causing invasive meningococcal disease and the isolated strains in the pharynx of asymptomatic carriers. To phenotypically and genotypically typify the isolations in order to identify the clones causing meningococcal disease in our environment and their relationship with currently available vaccines.
    • Assessment of the epidemiological impact of vaccination with conjugate vaccine and the ecological impact on invasive strains and saprophyte strains. We will particularly research the appearance of capsular exchange phenomena among strains of different serogroups and their possible relationship with the polysaccharide conjugate vaccine against meningococcus C.
    • Assessment of the differences between the protection given by the polysaccharide conjugate vaccine against meningococcus C when administered on its own, and the protection given by this vaccine when administered at the same time as other new vaccines such as the heptavalent pneumococcal conjugate.
    • Study of the genosubtypes of the meningococcus circulating in our region in order to assess the utility of a vaccine prepared with external membrane proteins.
  • Prevention of cervical cancer and Chlamydia infections: selection of the most suitable screening methods, the prevalence of persistent infections caused by papillomavirus and the causal genotypes.
    • Study of the prevalence of persistent infections caused by HPV in women over the age of 35 in our environment.
    • To study the distribution of HPV genotypes in our environment, to find out the importance of the genotypes with the greatest oncogenic power such as HPV-16 and HPV-18 (among others), compared with the existing vaccines that are already applicable to humans.
    • To evaluate the role of molecular methods (PCR or array) to detect HPV in the context of the screening programmes for the prevention of cervical cancer.
    • To analyse the cost-efficiency ratio of the different diagnostic screening strategies.
    • To analyse the repercussions of vaccines against HPV in the circulation of different HPV genotypes.
    • To discover the prevalence of Chlamydia infections in the female population of reproductive age in our environment, and to evaluate the opportunity of implementing different population screening strategies
    • To discover the circulating genotypes of Chlamydia.
  • Surveillance of other emerging and re-emerging diseases and the assessment of recently established vaccination programmes.
    • To maintain the epidemiological and microbiological surveillance of vaccine-preventable diseases.
    • To incorporate new surveillance systems related to molecular methods of detection and typification of pathogens.
    • To keep watch over the appearance of, and characterise, the microorganisms causing significant epidemics in Public Health.

Team Members

Name Surname
Center E-mail
Miriam Alkorta Gurrutxaga Donostialdea IHO
Ainara Arana Salaverría Donostialdea IHO
María Gomáriz Díaz Donostialdea IHO  
Milagrosa Montes Ros Donostialdea IHO
Eider Oñate Vergara Donostialdea IHO
Luis Darío Piñeiro Vázquez Donostialdea IHO
José Ramón Saénz Domínguez Donostialdea IHO  


Scientific Output


Published: 10 / 71

Influenza Vaccine Effectiveness in Preventing Outpatient, Inpatient, and Severe Cases of Laboratory-Confirmed Influenza.

Castilla J, Godoy P, Dominguez A, Martinez-Baz I, Astray J, Martin V, Delgado-Rodriguez M, Baricot M, Soldevila N, Mayoral JM, Quintana JM, Galan JC, Castro A, Gonzalez-Candelas F, Garin O, Saez M, Tamames S, Pumarola T, CIBERESP Cases Controls Influenza.

Clin. Infect. Dis. 2013; 57: 167-175. FI: 9.374 (Q1).

HTLV Spanish Study Grp. Development of Tropical Spastic Paraparesis in Human T-Lymphotropic Virus Type 1 Carriers Is Influenced by Interleukin 28B Gene Polymorphisms.

Treviño A, Lopez M, Vispo E, Aguilera A, Ramos JM, Benito R, Roc L, Eiros JM, De Mendoza C, Soriano V.

Clin. Infect. Dis. 2012; 55: 1-4. FI: 9.154 (Q1).

Pediatric Acute Lung Injury Epidemiology and Natural History Study: Incidence and outcome of the acute respiratory distress syndrome in children.

López-Fernández Y, Azagra AM, de la Oliva P, Modesto V, Sánchez JI, Parrilla J, Arroyo MJ, Reyes SB, Pons-Ódena M, López-Herce J, Fernández RL, Kacmarek RM, Villar J.

Crit. Care Med. 2012; 40: 3238-3245. FI: 6.330 (Q1).

GEIH REIPI-Ab2010 Grp. Monotherapy versus combination therapy for sepsis due to multidrug-resistant Acinetobacter baumannii: analysis of a multicentre prospective cohort.

Lopez-Cortes LE, Cisneros JM, Fernandez-Cuenca F, Bou G, Tomas M, Garnacho-Montero J, Pascual A, Martinez-Martinez L, Vila J, Pachon J, Rodriguez J.

J. Antimicrob. Chemother. 2014; 69: 3119-3126. FI: 5.439 (Q1).

What causes decreased erythromycin resistance in Streptococcus pyogenes? Dynamics of four clones in a southern European region from 2005 to 2012.

Montes M, Tamayo E, Mojica C, Garcia-Arenzana JM, Esnal O, Perez-Trallero E.

J. Antimicrob. Chemother. 2014; 69: 1474-1482. FI: 5.439 (Q1).

Characterization of plasmids carrying the bla 0(OXA-24/40) carbapenemase gene and the genes encoding the AbkA/AbkB proteins of a toxin/antitoxin system.

Mosqueda N, Gato E, Roca I, Lopez M, Ruiz de Alegria C, Fernandez F, Martinez-Martinez L, Pachon J, Cisneros JM, Rodriguez-Bano J, Pascual A, Vila J, Bou G, Tomas M, GEIH-GEMARA SEIMC REIPI.

J. Antimicrob. Chemother. 2014; 69: 2629-2633. FI: 5.439 (Q1).

HIV-2 viral tropism influences CD4+ T cell count regardless of viral load.

Trevino A, Soriano V, Poveda E, Parra P, Cabezas T, Caballero E, Roc L, Rodriguez C, Eiros JM, Lopez M, De Mendoza C.

J. Antimicrob. Chemother. 2014; 69: 2191-2194. FI: 5.439 (Q1).

Predictive factors for early mortality among patients with methicillin-resistant Staphylococcus aureus bacteraemia.

Gasch O, Camoez M, Domínguez MA, Padilla B, Pintado V, Almirante B, Lepe JA, Lagarde M, Ruiz de Gopegui E, Martínez JA, Montejo M, Torre-Cisneros J, Arnáiz A, Goenaga MA, Benito N, Rodríguez-Baño J, Pujol M.

J. Antimicrob. Chemother. 2013; 68: 1423-1430. FI: 5.338 (Q1).

Predicting non-invasive ventilation failure in children from the SpO(2)/FiO(2) (SF) ratio.

Mayordomo-Colunga J, Pons M, Lopez Y, Solana MJ, Rey C, Martinez-Camblor P, Rodriguez-Nunez A, Lopez-Herce J, Medina A, Abadesso C, Garcia-Teresa MA, Gaboli M, Garcia-Lopez M, Gonzalez-Sanchez M, Madurga-Revilla P, Gonzalez-Calvar A, Onate E.

Intensive Care Med. 2013; 39: 1095-1103. FI: 5.258 (Q1).

Gram-negative prosthetic joint infection: outcome of a debridement, antibiotics and implant retention approach. A large multicentre study.

Rodriguez-Pardo D, Pigrau C, Lora-Tamayo J, Soriano A, del Toro MD, Cobo J, Palomino J, Euba G, Riera M, Sanchez-Somolinos M, Benito N, Fernandez-Sampedro M, Sorli L, Guio L, Iribarren JA, Baraia-Etxaburu JM, Ramos A, Bahamonde A, Flores-Sanchez X, Corona PS, Ariza J, REIPI Grp Study Prosthetic.

Clin. Microbiol. Infect. 2014; 20: 911-919. FI: 5.197 (Q1).


Published: 0 / 0


Published: 5 / 5

Rotavirus G12 in Spain: 2004-2006.

Cilla G, Montes M, Arana A.

Enferm. Infec. Microbiol. Clin. 2014; 32: 405-0. FI: 1.881 (Q3).

Grp Espahol Para Estudio VIH-HTLV. Infection by HIV-2, HTLV and new human retroviruses in Spain.

Treviño A, Soriano V.

Med. Clin. 2012; 138: 541-544. FI: 1.385 (Q2).

Simultaneous urethritis and conjunctivitis caused by adenovirus type 56.

Idigoras P, Zapico MS, Montes M, Romano C.

Med. Clin. 2014; 142: 558-0. FI: 1.252 (Q3).

Infections due to human immunodeficiency virus type 2 and human T-Iymphotropic viruses in Spain.

Trevino A, Soriano V, Grp Espanol Estudio VIH-2 HTLV.

Med. Clin. 2014; 142: 323-326. FI: 1.252 (Q3).

Acute retinal necrosis due to herpes simplex virus type 1 within three years after a herpetic encephalitis.

Arruti M, Aldazabal M, Blanco A, Pineiro L, Soledad M, Gonzalez F, Lopez de Munain A.

Rev. Neurologia. 2014; 58: 45-46. FI: 0.926 (Q4).


Published: 4 / 4

Hand, Foot, and Mouth Disease Outbreak and Coxsackievirus A6, Northern Spain, 2011.

Montes M, Artieda J, Pineiro LD, Gastesi M, Diez-Nieves I, Cilla G.

Emerg. Infect. Dis. 2013; 19: 676-678. FI: 5.993 (Q1).

Emergence of resistance to daptomycin in a cohort of patients with methicillin-resistant Staphylococcus aureus persistent bacteraemia treated with daptomycin.

Gasch O, Camoez M, Dominguez MA, Padilla B, Pintado V, Almirante B, Martin C, Lopez-Medrano F, Ruiz de Gopegui E, Blanco JR, Garcia-Pardo G, Calbo E, Montero M, Granados A, Jover A, Duenas C, Pujol M. REIPI Study Grp, GEIH Study Grp.

J. Antimicrob. Chemother. 2014; 69: 568-571. FI: 5.439 (Q1).

Absence of Swedish New Variant Chlamydia trachomatis (nvCT) and C-trachomatis Genotype Distribution in Gipuzkoa, Spain, 2009-2010.

Piñeiro L, Unemo M, Cilia G

Acta Derm.-Venereol. 2012; 92: 185-186. FI: 3.176 (Q1).

Viral encephalitis in infancy Reply.

Flores-Gonzalez JC, Jordan-Garcia I, Turon-Vinas E, Montero-Valladares C, Tellez-Gonzalez C, Fernandez-Carrion F, Garcia-Iniguez JP, Onate-Vergara E, Rodriguez-Nunez A.

Revista De Neurologia. 2016; 62: 240-240. FI: 0,743 (Q4).


Published: 2 / 2

Necrosis retiniana aguda por virus herpes simple tipo 1 a los tres años de una encefalitis herpética.

Arruti M, Aldazabal M, Blanco A, Piñeiro L, Zapico MS, González F, López de Munain A.

Rev. Neurologia. 2014; 58: 45-46. FI: 0.926 (Q4).

Increased Susceptibility to Pneumococcal Disease in Sjögren Syndrome Patients.

Ercibengoa M, Alonso M, Marimon JM, Saenz JR, Perez E.

WJV. 2014; 1: 45-49. FI: 0.000 (Q0).


Projects 1 / 1

Detección de Helicobacter Pylory en biopsia, hilo de enterotest y heces. Estudio comparativo empleando métodos moleculares, cultivo o inmunocromatografía y elisa.

Investigador Principal: Milagrosa Montes Ros. Entidad Financiadora: Gobierno Vasco, Departamento de Salud. Año inicio: 2014. Año final: 2017.