En este apartado Web, podréis encontrar las actividades más destacadas relacionadas con el ámbito de la Investigación e Innovación Sanitaria.

 

19/12/19

Seminar: “Identifying new mechanisms of axonal degeneration and neuromuscular junction dynamics in Amyotrophic Lateral Sclerosis: one step closer to therapy”

Hizlaria / Ponente: Jone López-Erauskin, PhD– Investigadora postdoctoral en el Laboratorio del Profesor Don W. Cleveland en el Instituto Ludwig, Universidad de California San Diego (UCSD), La Jolla, California.

Data / Fecha: 2019ko abenduak 19 / 19 de diciembre de 2019.
Ordua / Hora:  13:00.
Lekua / LugarBiodonostia OIIko Formakuntza Aretoan, 3.Solairua. / IIS Biodonostia, Sala de Formación, Planta 3.

Laburpena / Resumen:

Licenciada en Biotecnología por la Universidad Autónoma de Barcelona (UAB), Máster en Biomedicina con especialidad en Neurociencias por la Universidad de Barcelona (UB) y Doctora en 2013 por la Facultad de Medicina de la Universidad de Barcelona (UB). Su carrera investigadora la inició estudiando la disfunción mitocondrial y el estrés oxidativo en enfermedad neurodegenerativa Adrenoleucodistrófia ligada al cromosoma X en el laboratorio de la Doctora Aurora Pujol (IDIBELL-Institut d’Investigació Biomedica de Bellvitge) en Barcelona. Desde el 2014 trabaja como investigadora postdoctoral en el laboratorio del Profesor Don Cleveland en la Universidad de California San Diego (UCSD), en La Jolla, California, estudiando las alteraciones celulares y moleculares que contribuyen a la Esclerosis Lateral Amiotrófica (ELA).

01/01/70

View requirements

13/12/19

Lectura de Tesis Doctoral / Tesiaren irakurketa: “Mecanismos fisiopatológicos del trastorno de control de impulsos en la enfermedad de Parkinson”

Doktoregaia / Doctoranda:
Irene Navalpotro Gómez. Área Neurociencias, IIS Biodonostia.
Tesi Zuzendaria / Directora de Tesis: 
Dra. María Cruz Rodríguez Oroz.
 
Data / Fecha: 2019ko abenduak 13, ostirala / Viernes 13 de diciembre de 2019.
Ordua / Hora: 11:30
Lekua / Lugar:
Donostia Unibertsitate Ospitaleko Ekitaldi Aretoa / Salón de Actos, Hospital Universitario Donostia.

Laburpena / Resumen:
La presente tesis se ha centrado en el estudio de los mecanismos fisiopatológicos del trastorno de control de impulsos en pacientes con enfermedad de Parkinson. A pesar de las importantes repercusiones de esta complicación, sus mecanismos fisiopatológicos son desconocidos, habiéndose descrito resultados contradictorios a múltiples niveles de estudio, pero especialmente en los estudios de imagen. Esta tesis se ha realizado no sólo con el ánimo de comprender los mecanismos por los que ocurre, sino también con el objetivo de ampliar las herramientas de detección de los sujetos que serán más sensibles al desarrollo de esta complicación tras el inicio de la terapia de reposición dopaminérgica.

01/01/70

View requirements

20/09/19

Seminario / Mintegia: “Environmental risk perceptions and determinant factors”


Hizlaria / Ponente:Jesús Ibarluzea PhD – Investigador Principal del grupo de Epidemiología Ambiental y Desarrollo Infantil (BIODONOSTIA) y del Grupo 28 de CIBERESP.
Data / Fecha: 2019ko irailak 20 / 20 de septiembre de 2019.
Ordua / Hora:  13:00 – 14:00.
Lekua / LugarBiodonostia OIIkoEkitaldi Aretoan, 0.Solairua. / IIS Biodonostia, Salón de Actos, Planta 0.

Laburpena / Resumen:

Our research group focus on the study of the associations between environmental exposures (e.g. chemical exposures like metals, endocrine disruptors, dioxins, PCBs, physical exposures as noise, electromagnetic fields and urban features such as greenness or walkability) and diverse health and developmental outcomes  (birth outcomes, respiratory diseases, obesity and a wide range of neuro-psychological indexes). It is obvious that we have to measure the objective presence of the former exposures but it is equally relevant to assess the perception general public has about them. These perceptions can help people protect themselves from such exposures but, if triggered by unrealistic contextual information, may lead to exacerbation of physical and psychological symptoms and inappropriate behavioral strategies.  The presenter will introduce a recently conducted study on the perception of a wide range of environmental exposures by a sample of gipuzkoan citizens and regional experts. He will explain the main variables behind risk perceptions and will elaborate on the public health policy implications of the results.

01/01/70

View requirements

11/06/19

Seminario / Mintegia: “ microRNAs in non-alcoholic fatty liver disease: from pathogenic elements to potential biomarkers and therapeutic targets”

Hizlaria / Ponente: Rui E. Castro (Ph.D) – Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa).
Data / Fecha: 2019ko ekainak 11 / 11 de junio de 2019.
Ordua / Hora:  9:30-10:30.
Lekua / LugarBiodonostia OIIko Ekitaldi Aretoan, 0.Solairua. / IIS Biodonostia, Salón de Actos, Planta 0.

Laburpena / Resumen:
Rui Castro graduated in Biology and Genetics and completed his PhD in Pharmacy (Biochemistry) by the Faculty of Pharmacy, University of Lisbon (FFUL) and Department of Medicine, University of Minnesota Medical School, USA. He is now Assistant Professor and Principal Investigator at the Research Institute for Medicines (iMed.ULisboa), FFUL. He is a strong promoter of basic and translational to clinical research in Hepatology, being a member of both the EASL Education Committee and the UEG Education E-Learning Team.
Castro’s research combines his solid background in the modulation of liver cell function by bile acids with his most recent discoveries in the miRNA field, to answer fundamental questions on the pathogenesis and therapeutic targeting of liver diseases, focusing on non-alcoholic fatty liver disease. Well-established in vitro and in vivo models, as well as human patients liver biopsies and serum samples, are being used in multi-layered pharmacological approaches, aiming to ultimately bring miRNA therapies and biomarkers to the liver clinical setting.

01/01/70

View requirements

06/06/19

Seminario/Mintegia: “Physically active microenvironments for tissue engineering applications”

Hizlaria / Ponente: : Senentxu Lanceros-Mendez. Ikerbasque Research Professor and Scientific Director at BCMaterials –Basque Center for Materials, Applications and Nanostructures, Derio, Spain.
Data / Fecha: 2019ko ekainak 6 / 6 de junio de 2019.
Ordua / Hora:  13:30-14:30.
Lekua / LugarBiodonostia OIIko Prestakuntza Aretoan 3.Solairua. / IIS Biodonostia, Sala de Formación, Planta 3.

Laburpena / Resumen:
Active materials are increasingly used in tissue engineering and regenerative medicine in order to provide specific clues to the cells. In particular, the use of electroactive polymers that deliver electrical signals to the cells upon mechanical solicitation, open new scientific and technological opportunities, allowing the development of suitable biomimetic microenvironments for tissue regeneration. In fact, electrical and electromechanical clues are among the most relevant ones in determining tissue functionality in tissues such as muscle and bone, among others, indicating their requirement for proper tissue regeneration.

This talk reports on active materials, such as piezoelectric and magnetoelectric, tailored for tissue engineering applications. The most used materials and morphologies are reported, together with novel bioreactor designs allowing to take full advantage of those materials.  The main achievements, challenges and future needs will be presented and discussed.

S. Lanceros-Mendez graduated in physics at the University of the Basque Country, Leioa, Spain. He obtained his Ph.D. degree at the Institute of Physics of the Julius-Maximilians-Universität Würzburg, Germany. He was Research Scholar at Montana State University, Bozeman, MT, USA and visiting scientist at the, Pennsylvania State University, USA and University of Potsdam. He is Ikerbasque Research Professor and Scientific Director at BCMaterials –Basque Center for Materials, Applications and Nanostructures, Derio, Spain and Associate Professor at the Physics Department of the University of Minho, Portugal (on leave). From 2012 to 2014 he was also Associate Researcher at the INL – International Iberian Nanotechnology Laboratory. His work is focused in the area of smart and multifunctional materials for sensors and actuators, energy and biomedical applications, with over 500 publications and 10 patents in the field.

01/01/70

View requirements

25/01/19

Lectura de Tesis Doctoral / Tesiaren irakurketa: “Molecular genetic diagnosis of patients from the Basque country with Inherited Retinal Dystrophies”

Doktoregaia / Doctorando:
Maitane Ezquerra Intxausti. Neuro-endekapen Sentsorialaren Taldea, Biodonostia OII / Grupo de Neurodegeneración Sensorial, IIS Biodonostia.
Tesi Zuzendariak / Directores de Tesis: 
Javier Ruiz Ederra.
David Otaegui Bichot. 
Data / Fecha: 2019ko urtarrilak 25, ostirala / Viernes 25 de enero de 2019.
Ordua / Hora: 12:00
Lekua / Lugar:
Donostia Unibertsitate Ospitaleko Ekitaldi Aretoa / Salón de Actos, Hospital Universitario Donostia.

Laburpena / Resumen:
Las distrofias hereditarias de la retina (DHR), son un grupo heterogéneo de enfermedades de distintos fenotipos clínicos que afectan principalmente a la retina. Existen más de 250 genes ligados a más de 20 fenotipos distintos. El avance en las técnicas de secuenciado ha permitido diagnosticar molecularmente a cada vez más pacientes, de una manera más rápida y precisa, a pesar de lo cual, el porcentaje de casos sin resolver sigue siendo alto.

A lo largo de la presente tesis, nos planteamos realizar la caracterización genético-molecular de la población de pacientes con DHR de Euskadi mediante distintas técnicas y poder implementar así un flujo de trabajo para poder llevarlo a cabo. Para ello, en este trabajo hemos utilizado distintas estrategias. Por un lado, se ha utilizado la tecnología de NGS. Utilizamos dos paneles: 1) genes con herencia autosómica dominante, en el que se analizaron pacientes con sospecha de herencia dominante de forma individualizada y 2) 316 genes de diversas patologías oftalmológicas, incluidas las DHR descritas hasta el momento, en el que se analizaron muestras agrupadas en pool de pacientes con todos los tipos de herencia. También hemos secuenciado el exoma completo (WES), para detectar alteraciones en genes no asociados previamente a DHR, y arrays CGH y MLPA para detectar cambios en el número de copias, tanto de genes asociados como no asociados previamente a DHR. Con el uso de todas estas técnicas, durante esta tesis, hemos podido diagnosticar molecularmente a 61 pacientes de un total de 143 pacientes analizados.

01/01/70

View requirements

18/01/19

Lectura de Tesis Doctoral / Tesiaren irakurketa: “Delivery of microRNAs as a remyelination strategy in Multiple Sclerosis”

Doktoregaia / Doctorando:
Iñaki Osorio Querejeta. Esklerosi Anizkoitzaren Taldea, Biodonostia OII / Grupo de Esclerosis Múltiple, IIS Biodonostia.
Tesi Zuzendariak / Directores de Tesis: 
David Otaegui Bichot.
Maider Muñoz Culla. 
Data / Fecha: 2019ko urtarrilak 18, ostirala / Viernes 18 de enero de 2019.
Ordua / Hora: 11:30
Lekua / Lugar:
Erizaintza Eskolako Gradu Aretoa / Salón de Grados de la Escuela de Enfermería. Donostia.

Laburpena / Resumen:
Multiple sclerosis is a central nervous system disease for which no remyelination therapy is nowadays available and alternative strategies are being proposed as myelin regeneration inductors. In this sense, the use of microRNAs, and more concretely miR-219a-5p has been shown promising results. However, the delivery of microRNAs to the central nervous system is still a tricky question.

In this work the role that miR-219a-5p plays in remyelination has been reinforce by using oligodendrocyte precursor cell primary culture, cerebellar organotypic model and experimental autoimmune encephalomyelitis mice model. In addition, the ability of Liposomes Nanoparticles and Exosomes as pro-remyelinating microRNA delivery systems has been addressed in the same models concluding that Exosomes is the most effective delivery system.

01/01/70

View requirements

20/12/18

Mintegia / Seminario: “Cancer engineering: designing of biomaterials as biomimetic niches for advancing pediatric cancer research”

Hizlaria / Ponente: Aranzazu Villasante. Institute for Bioengineering of Catalonia (IBEC).
Data / Fecha: 2018ko abenduak 20 / 20 de diciembre de 2018.
Ordua / Hora:  10:30.
Lekua / LugarBiodonostia OIIko Prestakuntza Aretoan, 3.Solairua. / IIS Biodonostia, Aula de Formación, Planta 3.

Laburpena / Resumen:
My overarching goal is to design biomaterials to closely mimic in vitro the biological and mechanical tumor microenvironment of pediatric cancers. Then with these models in hand, my objective is to learn fundamental information about drug resistance and tumor relapse. Thus, my main expertise brings together materials science, tissue engineering, and cancer biology.
I obtained my B.S. Degree in Biochemistry at the Complutense University of Madrid in 2005 and right after, I joined the Tumor Suppression group, led by Dr. Manuel Serrano, at the Spanish National Cancer Research Centre (CNIO). During my Ph.D., I investigated the epigenetic regulation of the Ink4a/Arf locus and the regulation of Sox2 in induced pluripotent stem cells (iPS).

Then in 2011, I joined the Vunjak-Novakovic lab in the Department of Biomedical Engineering at Columbia University in the city of New York. As a postdoc, I used novel biomaterials to develop biomimetic bioengineered models of Ewing’s sarcoma within the bone microenvironment. I also generated the first bioengineered model of tumor-derived exosomes. In parallel with my training in bioengineering at Columbia University, I was trained in pediatric diseases and collaborated with pediatricians at the Memorial Sloan Kettering Cancer Center.

Later, in 2015 I was appointed Associate Research Scientist at Columbia University, and I was awarded by the Japan Society for the Promotion of Science. This award gave me the opportunity to move to Tokyo for developing a vascularized tissue-engineered model of neuroblastoma at the Institute of Advanced Biomedical Engineering and Science. Later in 2016, I came back to NY to continue my research as an Associate Research Scientist at Columbia University.

Finally, in May 2018, I returned to Spain for a short stay in the Biomaterials, Biomechanics and Tissue Engineering Group in the Department of Materials Science & Metallurgy at UPC- BarcelonaTech. There, I designed bio-inks for bioprinting tissues for regenerative therapies, and I developed biomaterials in combination with nanoparticles to mimic osteosarcoma microenvironment.

Then, in December 2018, I joined the Samitier Lab (Nanobioengineering group) at the Institute for Bioengineering of Catalonia (IBEC) as a Senior Research Scientist with the support of the Spanish Association Against Cancer.

01/01/70

View requirements

20/12/18

Lectura de Tesis Doctoral: “Investigating the role of miRNA binding in B-cell lymphoma”

Doktoregaia / Doctorando:
Erika Larrea de Orte. Oncologia Molecularra, Biodonostia OII / Oncología Molecular, IIS Biodonostia.
Tesi Zuzendaria / Director de Tesis: Dr. Charles Lawrie.
Data / Fecha: 2018ko abenduak 20 / 20 de diciembre de 2018.
Ordua / Hora: 12:00h.
Lekua / Lugar:
Donostia Unibertsitate Ospitaleko Ekitaldi Aretoa / Salón de Actos, Hospital Universitario Donostia.

Laburpena / Resumen:

La expresión disfuncional de microRNAs es un fenómeno comúnmente observado en diferentes tipos de cáncer incluidos los linfomas B. Sin embargo, la relevancia funcional de esta desregulación a menudo se desconoce. Los linfomas B son un grupo heterogéneo de enfermedades neoplásicas caracterizado por la proliferación tumoral de linfocitos B, cuya incidencia va en aumento.

En la presente tesis doctoral se ha estudiado la relevancia de los sitios de unión de microRNAs en la patogénesis de dos de los linfomas B con mayor incidencia: el linfoma folicular (LF) y el linfoma difuso de célula grande B (LDCGB). Por un lado, se ha analizado la presencia y la relevancia funcional de mutaciones en sitios de unión de microRNAs en pacientes con LF. Por otro lado, se ha identificado el targetoma del microRNA-155 (conocido oncomiR en linfoma B) en LDCGB mediante la técnica experimental PAR-CLIP. Los resultados de esta tesis demuestran la relevancia de los microRNAs en linfoma B y la importancia de la identificación de sus genes diana para comprender el significado biológico de la expresión disfuncional de microRNAs a menudo identificada en cáncer.

01/01/70

View requirements

18/12/18

Mintegia / Seminario: “Tackling liver cancer by manipulating neutrophils and through exercise-induced stimulation of anti-inflammatory mechanisms”

Data / Fecha: 2018ko abenduak 18 / 18 de diciembre de 2018
Ordua / Hora:  10:00 – 11:00
Lekua / LugarBiodonostia OIIko Ekitaldi Aretoan, 0.Solairua / IIS Biodonostia, Salón de Actos, Planta 0.
Hizlaria / Ponente: Professor Derek A Mann.  Dean of Research and Innovation in the Faculty of Medical Sciences at Newcastle University, United Kingdom. 

Laburpena / Resumen:
Derek A Mann was appointed in 2006 Professor of Hepatology at Newcastle University following academic posts up to Chair position at the University of Southampton. Professor Mann is the Dean of Research and Innovation in the Faculty of Medical Sciences at Newcastle University. This role providing strategic leadership for all basic science research in the faculty. In addition, he is also responsible for providing scientific leadership and delivering high impact research into mechanisms responsible for the development of liver inflammation, fibrosis and cancer. A secondary responsibility is to translate this research into therapeutics for chronic liver disease.

Professor Mann’s main research role is as Director of the Newcastle Fibrosis Research Group (NFRG) providing strategic direction and leadership to its basic and clinical scientists who are focused on developing translational solutions to tissue remodelling and scar formation in the liver, lung, kidneys, heart and skin. The NFRG is primarily interested in understanding the molecular basis for liver fibrosis (scarring) and primary liver cancer. His research is supported by programme grants from the MRC, CRUK and NIAAA (NIH). Key recent discoveries include mechanisms of transgenerational epigenetic inheritance affecting fibrosis and a role for inflammatory neutrophils in hepatocellular carcinoma.

01/01/70

View requirements